• Potomac Photonics
  • February 05, 2024

Precision Laser Drilling of Glass Slides and Coverslips for Microfluidics and Biotech Applications

Precision Laser Drilling of Glass Slides and Coverslips for Microfluidics and Biotech Applications

Small holes in microscope slide. Hole diameters in picture are 200um, 500um and 1mm.

In the field of microfluidics, where precision is key to innovation and application success, our expertise at Potomac Photonics sets a standard. We specialize in the art of laser drilling precise small holes in glass slides and coverslips, a critical capability for the fabrication of microfluidic devices. These devices play a pivotal role in various scientific, pharmaceutical, and medical diagnostics applications, demanding not just skill but a deep understanding of the intricate needs of microfluidics.

Our Approach to Laser Drilling

At Potomac Photonics, we employ advanced laser technology to meticulously create tiny, accurate holes in substrates essential for microfluidic devices, such as glass slides and coverslips. This process is pivotal for the structural and functional integrity of microfluidic chips, allowing for the observation and manipulation of microscale fluid dynamics. Achieving holes as small as a few microns in diameter with extreme positional accuracy is complex and relies heavily on our extensive knowledge of laser physics, material science, and the specific demands of microfluidic applications.

Advantages of Our Laser-Drilled Microholes.                                                                                   

Laser cut Custom Glass Coverslips

Our laser drilling technique provides several significant advantages over conventional mechanical drilling methods:

Precision on the Micron Scale: We are capable of drilling holes with diameters in the micron range, essential for the intricate channels and chambers within microfluidic devices.
Unmatched Positional Accuracy: Our drilling process ensures each hole is exactly positioned, critical for the complex designs of microfluidic chips.
Integrity of Materials: The non-contact nature of laser drilling minimizes the risk of material damage, preserving the fragile glass substrates used in microfluidics.
Customizable Designs: Our method supports the creation of complex patterns and highly customized designs, facilitating the development of specialized microfluidic devices.

Applications Enabled by Our Precision Drilling

Our precision laser drilling capabilities are vital across several microfluidic applications:

Lab-on-a-Chip Devices: These compact devices integrate multiple laboratory functions on a single chip, where precise fluid manipulation is essential.Drug Development: Our microfluidic platforms are instrumental in high-throughput screening for drug discovery, requiring precise fluid control.
Diagnostic Tools: In diagnostics, our devices process small volumes of bodily fluids accurately, thanks to precisely drilled inlets and outlets.

Our Commitment to Innovation

Micro hole drilling in glass

At Potomac Photonics, we pride ourselves not just on our technical capabilities but on our dedication to pushing the boundaries of what’s possible in microfluidic device fabrication. Understanding our clients’ needs, whether they are in academia, industry, or healthcare, is at the core of what we do. This customer-focused approach, combined with our technical expertise, makes us a trusted partner in the microfluidics field.


The role of precision laser drilling in enabling the next generation of microfluidic devices is crucial. At Potomac Photonics, our expertise in creating ultra-small, precisely placed holes in glass substrates is not just a service; it’s a foundation for innovation in microfluidics and beyond. Whether advancing scientific research, developing new medical diagnostics, or enhancing drug discovery processes, our laser drilling capabilities are at the forefront of microscale technological advancement.

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